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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 42.12
Human Site: S518 Identified Species: 66.19
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 S518 I L N V R E A S H K Q I M E N
Chimpanzee Pan troglodytes XP_516332 1634 184611 S526 I L N V R E A S H K Q I M E N
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 S512 I L N V R E A S H K Q I M E N
Dog Lupus familis XP_534241 2041 231068 S936 I L N V R E A S H K Q I M E N
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 S506 I L N V R E A S H K Q I M E N
Rat Rattus norvegicus P41516 1526 173202 S495 I L N V R E A S H K Q I M E N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 S821 I L N V R E A S H K Q I M E N
Chicken Gallus gallus O42131 1627 183228 S523 I L N V R E A S H K Q I M E N
Frog Xenopus laevis NP_001082502 1579 178601 S495 L L N V R E A S H K Q I M E N
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 T517 I L N V R E A T H K Q I M E N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 K430 D A N E A G G K N S I K C T L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 L503 E G D S A K T L A V S G L S V
Sea Urchin Strong. purpuratus XP_783546 1448 163750 G431 V K A A A N C G I V E N I L S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 T456 G K N S R L C T L I L T E G D
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 A411 A D A N E E N A L K K S D G T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 100 93.3 93.3 N.A. 6.6 N.A. 0 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 13.3 N.A. 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 14 7 20 0 67 7 7 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 14 0 0 0 0 0 7 0 0 % C
% Asp: 7 7 7 0 0 0 0 0 0 0 0 0 7 0 7 % D
% Glu: 7 0 0 7 7 74 0 0 0 0 7 0 7 67 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 7 7 0 0 0 7 7 7 0 0 0 7 0 14 0 % G
% His: 0 0 0 0 0 0 0 0 67 0 0 0 0 0 0 % H
% Ile: 60 0 0 0 0 0 0 0 7 7 7 67 7 0 0 % I
% Lys: 0 14 0 0 0 7 0 7 0 74 7 7 0 0 0 % K
% Leu: 7 67 0 0 0 7 0 7 14 0 7 0 7 7 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 67 0 0 % M
% Asn: 0 0 80 7 0 7 7 0 7 0 0 7 0 0 67 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 67 0 0 0 0 % Q
% Arg: 0 0 0 0 74 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 14 0 0 0 60 0 7 7 7 0 7 7 % S
% Thr: 0 0 0 0 0 0 7 14 0 0 0 7 0 7 7 % T
% Val: 7 0 0 67 0 0 0 0 0 14 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _